Cognition is the process of understanding, learning, remembering and reasoning: it requires the highest level of our brain function. Just as these healthy mental processes are complex, so are the various forms of cognitive impairments, whether they are mild or severe, short-lived or permanent. Given our current state of knowledge, it is believed that the most serious forms of memory loss, such as dementia, are in fact slowly progressive neuro-degenerative illnesses. Presently approved pharmaceutical-based treatments offer only marginal help, and as of yet there are no effective approaches that can reverse or arrest the advancement of these ailments. Additionally, current drugs that target the main aspects of the disease process have demonstrated little or no clinical benefit.

There is a growing appreciation that the patho-genesis of cognitive disorders is multi-factorial: abnormal protein deposits, inflammation, signaling pathways, calcium and heavy metal imbalances, just to name a few, interact in a highly complex manner to provoke a self-sustaining and spiraling cascade of pathology, which automatically drives disease progression. When considering the perplexity of such maladies, it is not surprising that current drugs aimed at targeting single molecules are usually ineffective against complex diseases with a multi-factorial patho-genesis. Combination therapies or multi-target drugs might be more efficacious in controlling such illnesses1,2.

Life-style changes including a healthy diet and exercise, are known to improve many chronic diseases such as diabetes, high blood pressure, obesity and cardio-vascular disorders, etc. While there is no panacea to cure dementia, evidence attesting to the importance of nutrition in mitigating the development and progression of Alzheimer’s disease continues to accumulate. Given the very complex underlying patho-mechanisms, it is not surprising that many clinical studies investigating the benefits of individual vitamins or supplements show marginal, if any, benefit. However, new findings with combinatorial formulations show encouraging improvement in cognitive performance and behavioral difficulties that accompany Alzheimer’s disease3,4. In line with this knowledge, each capsule typically provides:

  1. Whitehouse PJ, George DR. Is there Alzheimer’s disease? J. Alzheimers Dis. 2015; http://j-alz.com/editors-blog/posts/is-there-alzheimers-disease
  2. Pistollato F, Ohayon EL, Lam A, Langley GR, Novak TJ, Pamies D, Perry G, Trushina E, Williams RS, Roher AE, Hartung T, Harnad S, Barnard N, Morris MC, Lai MC, Merkley R, Chandrasekera PC. Alzheimer disease research in the 21st century: past and current failures, new perspectives and funding priorities. Oncotarget 2016; 7(26): 38999-39016.
  3. Shea TB, Remington R. Nutritional supplementation for Alzheimer’s disease? Curr. Opin. Psychiatry 2015; 28(2): 141-147.